Long-term use of antibiotics can damage a middle-aged woman’s brain and even increase her risk of developing Alzheimer’s disease, according to a new study.
Researchers from Harvard University, Cambridge, Massachusetts, and Rush University, Chicago, Illinois, found that women in their 50s who took antibiotics for at least two consecutive months scored consistently worse on cognitive tests.
The score included measures of processing speed, brain function, attention and memory capacity.
The researchers write that antibiotic use makes women three to four years older than their peers and even increases their risk of developing devastating cognitive impairments later on.
Women in their fifties who have taken antibiotics for at least two months have a higher risk of developing Alzheimer’s disease and score worse on cognitive tests (archive photo)
The researchers, who published their findings in PL last week, collected data from more than 14,000 women who participated in the biennial Nurses’ Health Study II.
As part of the study, women would report, among other questions, whether they had taken any medication in the past two years and whether they had any health problems.
In 2009, a question about antibiotics was also included in the survey when most of the participants were over the age of 50.
Seven years later, in 2016, women were given a cognitive exam to identify various cognitive factors.
Women who reported taking antibiotics for at least two consecutive months generally performed worse than their peers.
There was a clear sign of cognitive decline over time, as middle-aged women who turned away from antibiotic use got worse.
The exact mechanism by which antibiotics have such a dire effect on the brain cannot be determined, but experts have a possible skepticism.
Researchers point to the gut-brain axis for the cognitive decline women experience.
A person’s gut has more control over their body and brain than previously thought, and previous research has even shown that the gut microbiome can determine a person’s personality.
Previous studies have also shown that gut health is linked to cognitive impairments such as Alzheimer’s disease and others in both humans and animals.

Because the body’s gut microbiome has great control over processes in the body, and bacteria in the microbiome are damaged by drugs, experts have long known that antibiotics can affect cognitive process.
The gut microbiome is affected by antibiotics, which can kill and replace the body’s stomach population.
As early as Hippocrates in 400 BC, people knew of a connection between internal bodily processes and outward manifestations of personality and other cognitive functions.
In 2016, Johns Hopkins University researchers found that antibiotic treatments can alter a person’s gut microbiome and, as a result, harm people with psychiatric disorders.
“More research is needed, but our research shows that if we can prevent infections and minimize antibiotic therapy in people with mental illness, we can prevent manic episodes from occurring,” he said. Written by Robert Yolken, a research fellow at the Baltimore, Maryland school.
Why the microbiome has so much control over the body has not been determined, but it has been studied by experts for decades.
Source: Daily Mail

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