New vaccine developed by BioNTech and Genentech could prevent pancreatic return, deadliest cancer –

New vaccine developed by BioNTech and Genentech could prevent pancreatic return, deadliest cancer –

Experts praised a cutting-edge vaccine that could prevent pancreatic cancer from returning.

Early research findings show that personalized vaccines prepare the body to prevent the deadly disease from returning.

Only a quarter of patients survive a year or more after diagnosis, and pancreatic cancer often goes undetected because the immune system does not detect the cancer cells as a threat.

But a small subset of patients outweigh the possibilities after tumor removal. At Memorial Sloan Kettering Cancer Center in New York, Dr. A team led by Vinod Balachandran found that their tumors contained large numbers of pathogen-destroying T cells.

New vaccine developed by BioNTech and Genentech could prevent pancreatic return, deadliest cancer –

Expert praises a cutting-edge vaccine that could prevent pancreatic cancer from returning (archive photo of a woman about to be injected)

They designed a study that included 16 people with pancreatic cancer who received special vaccines after surgery.

The vaccine uses a piece of the tumor’s genetic code to teach cells to make a protein that will trigger an immune response.

This allows the body to “recognize” the cancer as a threat and if it returns, the T cells will destroy it. In eight of the participants, the vaccine activated T cells to recognize the disease. After 18 months, they were cancer-free.

Dr. Balachandran told the American Society of Clinical Oncology annual conference in Chicago: “All treatments for pancreatic cancer are currently largely ineffective.

“Initial results suggest that if you have an immune response, you may have a better outcome.”

Dr. Chris MacDonald, head of UK Pancreatic Cancer research, said a tailor-made vaccine would be “a new key weapon against the deadliest common cancer” (archive photo from a division of the UK’s National Health Service)

Most of the patients who did not respond to the vaccine saw the cancer return, and some died.

The vaccine was developed with pharmaceutical giant BioNTech and US company Genentech, which uses similar mRNA technology to make the Covid vaccine.

Dr. Chris MacDonald, head of UK Pancreatic Cancer research, said a personalized vaccine would be “a vital new weapon against the deadliest common cancer”.

In the UK, around 10,500 people are diagnosed with the disease each year, and 9,600 of them die.

What is pancreatic cancer?

Pancreatic cancer is one of the deadliest forms of the disease, and about 95% of people who get it die from it.

Joan Crawford, Patrick Swayze and Luciano Pavarotti died of pancreatic cancer.

It is the sixth most common cause of cancer-related death in the UK – around 10,000 people in the UK and around 55,000 in the US are diagnosed with pancreatic cancer each year.

WHAT IS THE REASON?

It is caused by the abnormal and uncontrolled growth of cells in the pancreas, a large gland in the digestive tract.

WHO IS AT THE HIGHEST RISK?

Most cases (90%) involve people over the age of 55.

About half of all new cases occur in people 75 years and older.

One out of every 10 cases is attributed to genetics.

Other possible causes include age, smoking, and other health problems, including diabetes.

WHY IS IT SO FATAL?

There is no screening method for pancreatic cancer.

Pancreatic cancer usually causes no symptoms in the early stages, when it is more manageable.

Patients tend to develop prominent symptoms such as jaundice and abdominal pain around stage 3 or 4, where it is most likely to have spread to other organs.

WHAT ARE THE TREATMENT OPPORTUNITIES?

The only effective treatment is removal of the pancreas.

This is largely ineffective for those whose cancer has spread to other organs.

In these cases, palliative care is recommended to relieve pain at the end of their life.

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Source: Daily Mail

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