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Deadly Marburg virus causes first outbreak in another African country: Five dead in Tanzania and more than 100 feared to contract a 90 percent killer

One of the world’s deadliest diseases has spread to another African country for the first time.

The Marburg virus – which kills 90 percent of patients and has no cure – has killed five people in Tanzania, including a health worker, while three more patients are being treated in hospital.

The falls are in the northern city of Bukoba in Kagera province, which is home to 120,000 people. More than a hundred residents who feared they had been exposed to the virus are now under surveillance.

Marburg – an Ebola-like disease that causes fever, vomiting and profuse bleeding from the eyeballs, nose and gums – is endemic to parts of central Africa, including Angola and the Democratic Republic of Congo. It has also previously appeared in Kenya.

But the new outbreak comes barely a month after Marburg virus first hit Equatorial Guinea on the other side of the continent.

The map above shows where Marburg virus is endemic (red) and the two countries where it was first detected this year (yellow). It also shows the provinces of those countries where they were discovered (bright yellow).

The Marburg virus has an incubation period of up to 21 days.  The virus attacks the kidney and spleen, causing blood clots and inflammation throughout the body.  Symptoms can be very serious, such as skin rash, eye bleeding and delirium.  A high percentage of cases result in death and even survivors suffer permanent damage.  Pictured: Ebola patients belonging to the same virus family as Marburg

The Marburg virus has an incubation period of up to 21 days. The virus attacks the kidney and spleen, causing blood clots and inflammation throughout the body. Symptoms can be very serious, such as skin rash, eye bleeding and delirium. A high percentage of cases result in death and even survivors suffer permanent damage. Pictured: Ebola patients belonging to the same virus family as Marburg

Five of the eight patients in the north of the country have died.

The cases were diagnosed after tests carried out at the country’s main laboratory in the capital, Dar es Salaam.

A rapid response team with staff from the World Health Organization has now been deployed to contain the outbreak.

It is not clear how the patients were infected, but Marburg virus can be transmitted through contact with a patient’s blood or fluid.

What are the symptoms of Marburg? Can it spread as fast as Covid? Questions answered

Marburg, one of the deadliest pathogens ever discovered, has already killed nine in Equatorial Guinea and another five in Tanzania.

Matshidiso Moeti, WHO’s regional director for Africa, said: “We are working with the government to rapidly scale up control measures to stop the spread of the virus and end the outbreak as soon as possible.

“Lessons learned and progress made in other recent outbreaks should benefit the country in this latest challenge.”

Moeti said that although Tanzania had not previously dealt with Marburg, it had recently faced a number of health emergencies, including Covid, cholera and dengue fever.

Marburg virus has been touted as the next major pandemic threat, with the WHO calling it “epidemic prone”.

It can be spread to humans via fruit bats that live in central Africa, and can also be spread between humans through contact with bodily fluids of an infected person. People can also contract the disease by touching towels or surfaces that have also been in contact with an infected person.

Marburg virus can incubate in people it infects for two to 21 days before causing symptoms.

But warning signs, when they do break out, initially look like other tropical diseases like Ebola and malaria.

Infected patients become “spooky” and often develop deep-set eyes and expressionless faces.

But in later stages, it causes bleeding from various body openings, including the nose, gums, eyes and vagina.

No vaccines or treatments have been approved for the virus, and doctors must instead rely on drugs to relieve symptoms and fluids to keep patients hydrated.

The outbreak in Tanzania follows weeks after another in Equatorial Guinea on the other side of the continent.

The country’s authorities are keeping a low profile on the situation on the ground, but have not issued an update since late February.

MVD has a mortality rate of up to 90 percent.  There are currently no approved vaccines or treatments to treat the virus

MVD has a mortality rate of up to 90 percent. There are currently no approved vaccines or treatments to treat the virus

Marburg virus (MVD) is first transmitted to humans by fruit bats and spreads among humans through direct contact with bodily fluids, surfaces and materials of infected humans.

However, its latest update said 11 people have died from the virus in a northern province of the country. At least 16 are reported to be infected, while 48 are also under surveillance.

Cases occurred in early January and the last one was said to have become infected at the end of February.

Two villages in the northern region of Kie-Ntem province on the border with Cameroon were hit.

Two children in Cameroon were also suspected of having the Marburg virus, but this was later denied by the country’s health authorities.

Everything you need to know about Marburg: What are the symptoms? How does it spread? Will it reach the United States?

How deadly is Marburg?

Marburg is one of the deadliest pathogens known to man.

The WHO speaks of a case fatality ratio (CFR) of up to 90 percent.

But experts estimate it’s probably closer to 50 percent, similar to its cousin Ebola — another member of the Filoviridae family.

This means that half of the 100 confirmed Marburg-infected people are expected to die.

However, scientists don’t know the death rate from infection, which measures everyone who becomes infected — not just those who test positive.

By comparison, Covid had a CFR of around three percent when it was introduced.

What are the telltale symptoms?

Symptoms come on suddenly and include severe headache, fever, diarrhoea, abdominal pain and vomiting. You are getting more and more serious.

In the early stages of MVD – the disease that causes it – it is very difficult to distinguish it from other tropical diseases such as Ebola and malaria.

Infected patients become “spooky” and often develop deep-set eyes and expressionless faces.

It is usually accompanied by bleeding from various body openings, including the nose, gums, eyes and vagina.

Like Ebola, even dead bodies can transmit the virus to people exposed to the fluids.

How does the virus spread?

Human infections usually begin in areas where people have long-term exposure to mines or holes inhabited by infected fruit bat colonies.

Fruit bats naturally harbor the virus.

However, it can then spread between people through direct contact with bodily fluids, surfaces and materials of infected people.

Contaminated clothing and bedding also pose a risk, as do funeral ceremonies that involve direct contact with the deceased.

In Equatorial Guinea, the virus was found in samples from deceased patients suffering from symptoms such as fever, fatigue and bloody vomiting and diarrhoea.

Health care workers were often infected when they treated patients in Marburg.

Gavi, an international organization that promotes access to vaccines, says people in Africa should avoid eating or handling bushmeat.

Is there a vaccine?

No vaccines are currently approved to treat the virus.

On Monday, the WHO convened an emergency meeting on the rising cases and called in experts from around the world.

Members of the Marburg Virus Vaccine Consortium (MARVAC) told the WHO that it could take months before effective vaccines and therapies are available because manufacturers need to collect materials and conduct trials.

Experts have identified 28 experimental vaccine candidates that could be effective against the virus – most of which are designed to fight Ebola.

Five were specifically highlighted as vaccines to be studied.

Three vaccine developers – Janssen Pharmaceuticals, Public Health Vaccines and the Sabin Vaccine Institute – said they may be able to make doses available for testing during the current outbreak.

The Janssen and Sabin vaccines have already passed phase 1 clinical trials. However, none of the vaccines are available in large quantities.

The Public Health Vaccines bite monkeys have also recently been found to protect against the virus, and the Food and Drug Administration has approved them for human testing.

How bad were previous Marburg clusters and where were they?

Before this outbreak, only 30 cases were recorded worldwide between 2007 and 2022.

Angola in central Africa experienced its largest known outbreak in 2004. It had a 90 percent fatality rate, with 227 deaths among 252 infected, according to the Angolan government.

Last September, Ghana declared the end of a Marburg outbreak that had hit the Ashanti, Savannah and western regions of the country.

Can it reach UK or US?

Most Marburg outbreaks disappear after a few people are infected.

As a result, experts say the chances of it causing a pandemic are slim. And yet it is not impossible.

Professor Whitworth told MailOnline yesterday: “Outbreaks from Marburg are always worrying because of the high mortality rate and the possibility of person-to-person transmission through close contact.”

The speed with which the outbreak in Equatorial Guinea was spotted by officials may have helped dampen the spread of the infection so far, he advised.

He said: “This outbreak has occurred in a remote forested area of ​​Equatorial Guinea, which limits the likelihood that it will spread quickly or affect many people.

“It also seems to have been noticed quickly, the number of suspected cases is low and the first investigated death occurred on January 7, so only about five weeks ago.”

But he added: “The outbreak occurred close to the international border with Cameroon and Gabon, so international coordination is needed.

“So the risk to Equatorial Guinea and the region overall is moderate and the risk of spread outside the region is very low.”

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