This pill without hormones could change everything for male contraception

YCT-529: the promise of a non-hormonal contraceptive pill is becoming clearer

While contraception is still largely based on the shoulders of women, a new male candidate attracts attention. The YCT-529, a molecule developed by Yourchoice Therapeutics, sees a new path: that of a non-hormonal oral contraceptive for men. The first clinical results on man are encouraging, we learned on 30 July 2025.

An evident need for solutions for men

With almost one in two pregnancy not planned in the world, the contraceptive offer remains limited, especially from the male side. Today there are only two options: condoms, unreliable long -term (bankruptcy of 13 %) and vasectomy, an often irreversible surgical solution. The YCT-529 therefore responds to the need for crying of effective, reversible and easy-to-use methods.

An innovative way of acting without hormonal impact

The YCT-529 acts by targeting the Rar-α receiver, essential for the production of sperm. Unlike hormonal solutions, this approach does not change testosterone levels or other sex hormones.

This specificity makes the pill interesting to avoid the side effects often observed with hormonal treatments: mood disorders, altered or acne.

A first reassuring clinical phase

In this phase 1st study conducted in the United Kingdom, 16 volunteer men received several unique doses from YCT-529, from 10 to 180 mg, on an empty stomach or after a meal. No serious side effects were found. Apart from some headaches or benign infections comparable to those that occur in the placebo group, a single participant has presented a benign arrhythmia of gravity, probably linked to the drug.

The analyzes have shown that the molecule did not interrup hormones, inflammation markers, cardiac function. Libido and mood also remained stable, according to the psychosexual newspapers held by the participants.

A step towards a reversible and effective treatment

Although the effect of Ict-529 on the actual production of sperm has not yet been evaluated in humans, tests on mice and primates had shown a reversible inhibition of spermatogenesis. The drug remains in the body for several days, but a daily socket is evaluated in a phase 1b/2nd study for 28-90 days.

What does it mean for couples

This development represents a rotating potential in the contraceptive load shared within couples. If confirmed effective and without long-term side effects, the YCT-529 could offer men a serious alternative to current solutions and women, a more equitable sharing of contraceptive responsibility.

An arrival on the market still far away

We are only at the beginning: Several years of testing are still needed before a possible marketing. But the first results finally give the body to a often push promise: that of a male contraceptive, safe, reversible and non -hormonal pill. An advance that many couples have been waiting for a long time.