Women taking antidepressants for PMS may only need two weeks a month –

According to one study, women taking antidepressants to deal with premenstrual mood problems may only need to take the pill for two weeks a month.

Researchers from Maudsley Hospital in South London added that this intermittent dosing regimen is as effective as taking continuous tablets at controlling symptoms and can help patients avoid drug addiction and withdrawal.

The team came to this conclusion after analyzing eight studies involving 460 women with either severe premenstrual syndrome (PMS) or premenstrual dysphoric disorder, both of which have been linked to fluctuating hormone levels that cause mental health problems.

Common antidepressants known as selective serotonin reuptake inhibitors (SSRIs) have all been prescribed to relieve symptoms.

Some received the treatment daily, while others followed the luteal phase dosing regimen. This involves starting the pills on day 14 of the monthly cycle – the luteal phase where ovulation happens – and taking them for two weeks, then stopping on the first day of the next cycle.

The analysis found no significant differences in response rates and symptoms between the two groups, leading them to conclude that the spaced-dose approach was equally effective.

It is estimated that around 30% of women suffer from moderate to severe PMS, which is characterized by painful physical, behavioral and psychological changes.

Symptoms include mood swings, depression, fatigue, irritability and aggression. Swelling, breast tenderness, clumsiness, headaches and weight gain are also common.

Researchers from Maudsley Hospital in South London added that this intermittent dosing regimen is as effective as taking continuous tablets at controlling symptoms and can help patients avoid drug addiction and withdrawal. (archive photo)

Premenstrual dysphoric disorder affects 5% to 8% of patients. While reducing stress, eating healthy foods and limiting alcohol can reduce symptoms, hormone treatments or SSRI antidepressants are often prescribed to help people with the worst problems.

The researchers concluded that the intermittent dosing regimen is an important option: “As the SSRI is not taken continuously, the risk of withdrawal symptoms is limited.”

“I welcome any research into the impact of the menstrual cycle on mental health – which means researchers are finally taking it seriously,” said women’s health expert Dr Philippa Kaye.