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How can 150 be the new 70 thanks to anti-aging technology?

Leading experts say babies born in 2070 could live up to 150 years thanks to advances in reverse aging technology.

This could not only double the current global average life expectancy, but also reduce the time people spend on age-related diseases.

What was once considered a distant utopia is getting closer to reality earlier this month following a groundbreaking study that successfully reversed the aging process in aged mice.

Scientists now estimate that the technology may be ready for humans in a few decades.

Dr. Andrew Steele, a computational biologist and author of Ageless: The New Science for Aging Without Aging, said human evidence will soon be on the horizon.

“You would be stupid if you bet that it won’t work for the next 50 years,” he said.

Professor Jürg Bähler, a geneticist at University College London, has predicted that such technology could extend the lifespan by up to a century and a half.

“Some people, myself included, would say there’s a natural ceiling for human life, about 150 and you can’t go beyond that,” he said.

Life expectancy for men and women born in the UK today is 79 years for men and 82.9 years for women.

In the United States, life expectancy for children born in 2020 is significantly lower at 74.2 years for men and 79.9 years for women.

Anti-aging experts say babies born in 2070 could live to be 150 years old, following recent findings to reverse the aging process in mice (image file)

The experts’ comments came just weeks after a team of scientists from the Salk Institute in San Diego reversed the aging process in middle-aged and older mice using a cellular “rejuvenation” technique.

Using four molecules known as Yamanaka transcription factors, they were able to partially restore mouse cells to “younger states.”

Scientists have successfully reversed aging in mice using the cellular “rejuvenation” technique, claiming it could work in humans.

Using a cellular “rejuvenation” technique, the scientists reversed the aging process in middle-aged and older mice.

California-based experts partially restore mouse cells to “younger states” using four molecules known as Yamanaka transcription factors.

After injecting these molecules into mice of different ages, the animals’ kidneys and skin showed promising signs of rejuvenation, while skin cells were more proliferative and less likely to form permanent scars.

Their “safe” treatments may one day help people turn back their biological clocks and reduce their risk of cardiovascular disease and cancer, the researchers said.

According to the results, a treatment period of seven to 10 months may be required to prevent the unwanted side effects of aging.

Some previous experiments with cell rejuvenation caused cancer development or organ failure in mice, but not in this latest experiment.

Although previous experiments with Yamanaka factors counteracted signs of aging and prolonged life expectancy in mice reared with premature aging disease, the most recent study was the first to test this in normal mice.

Yamanaka factors essentially reset the molecular clock in animal cells, returning them to a younger and more adaptable state.

After injecting these molecules into mice of different ages, the animals’ organs and skin showed signs of rejuvenation.

Dr. “We put the platform to work in humans and the concept in mice,” Steele said.

“I don’t think it would be that crazy to see reprogramming through rejuvenation in the next 10, 15, 20 years.”

He said this could take a form similar to gene therapy, in which a person’s genes are altered by infecting them with a harmless virus that has been genetically modified to replace or inactivate a faulty gene.

“We’re already using gene therapy in humans,” he said.

‘It’s still in its infancy, but it’s an existing technology. It feels like decades instead of centuries before we get really good at it.

Some skeptics of lifespan argue that it could lead to overpopulation or be confined to the ultra-rich, causing further social division.

Based on the lack of adverse outcomes in mice, the San Diego researchers said their treatment should be “safe” in humans.

How do cells age and how can the process be reversed?

As organisms age, every cell in their body carries a molecular clock that records the passage of time.

Cells isolated from older humans or animals have different chemical patterns in their DNA, called epigenetic markers, unlike younger ones.

The scientists found that by adding a mixture of four reprogramming molecules called Yamanaka transcription factors to the cell, these epigenetic traits can be restored to their original pattern.

This actually makes cells younger.

However, experiments have shown that this does not happen directly, with mouse studies showing results only when rodents are treated with Yamanaka for 7-10 months.

hope it helps People reduce their risk of cardiovascular disease and cancer by turning their biological clocks back.

According to the results, a treatment period of seven to 10 months may be required to prevent the unwanted side effects of aging.

Gene therapy is already available on the NHS for a variety of genetic conditions, including metachromatic leukodystrophy, a rare condition that damages a child’s nervous system and organs and dramatically shortens their lifespan.

Professor Bähler said that while other previous increases in life expectancy have allowed people to live longer, but often be sicker, there won’t be much of a downside to tackling the cellular aging process.

“There has been a huge increase in life expectancy over the last 200 years, from 30-40 years today to 80,” he said.

“But what’s happening is that people live longer and get sick longer. They still have cancer at the same age, all these different morbidities.

“But if you change the underlying process, you help people stay healthy longer.”

Dr. However, Steele added that aging is a complex process and cellular rejuvenation is not the only solution for a longer life.

“Think about proteins like collagen — it’s the most abundant protein in your body, and its function changes with age,” he said.

“It’s outside of your cells, so rejuvenating your cells doesn’t seem to be able to change it.”

Source: Daily Mail

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