An unnamed Connecticut resident has been infected with COVID-19 for over a year, and scientists have even found that the virus has mutated multiple times in it.
Researchers at Yale University discovered the 60-year-old patient, who has a form of lymphoma, after tracking down a variant suspected to be extinct.
Upon further examination, they found that the person’s blood had three different sublines of the virus, suggesting that they were a vector for mutation.
This is the longest Covid infection discovered by healthcare professionals, adding to the growing evidence that the virus mutates in immunocompromised individuals before continuing to spread to others.
An unnamed person in his 60s who also has lymphoma has an active Covid infection for more than 470 days. They also have three different lines of viruses circulating in their blood (archive photo)
The case study is currently available in preprint on MedRxive and awaits peer review before publication.
Surveillance of strains of Covid in Connecticut, where Yale is based, found a B.1,517 strain circulating in the area last year that had not been seen worldwide for a while.
All of the infections were traced back to a patient living in an unknown part of the state.
Further investigation revealed that they suffered from “chronic Covid” and tested positive for the virus for at least 471 days. At the time of publication on Saturday, the patient was still testing positive for the virus.
They also found that the virus mutated rapidly in their bodies at an unusual rate for a typical infection.
It mutated twice as fast, resulting in three completely separate and distinct genotypes of the virus.
“This chronic infection resulted in an accelerated evolution and divergence of SARS-CoV-2, a mechanism that may contribute to the emergence of genetically diverse SARS-CoV-2 variants, including Omicron, Delta, and Alpha,” the researchers wrote.
The case is one of the first and longest discovered infections of “chronic Covid”.
Although “Long Covid” is a phenomenon that experts have been aware of for some time, it occurs when a person feels symptoms of the virus even after the infection has passed.


However, this infection is different as the unnamed person is an active Covid case and the virus test continues to be positive for a long time.
It also adds to the growing literature showing that the virus specifically exploits immunocompromised people to mutate.
Last year, doctors in England found that the virus was rapidly mutating in the body of a man who also suffered from lymphoma. He would later succumb to his illness.
This discovery opened up the theory that the virus could create “escape mutations” that allow it to escape antibodies and remain in the genetic code.
Since then, there have been other scattered reports of people with serious comorbidities such as cancer and experiencing rapid mutations of the virus.
However, it is impossible to know how many people carry a rapidly mutating virus, and there is little that experts can do to prevent Covid from mutating frequently once a suitable host is found.
The rapid mutation of the virus is a danger, because every time a massively new version of Covid emerges, it engulfs the world, leaving the authorities struggling to face a new threat.
The Delta variant, which originated in India, triggered one of the deadliest outbreaks of the virus to date when it exploded worldwide in the spring and summer of 2021.
Late last year, the Omicron variant crossed the Earth and caused record levels in almost every country it touched, while also erasing much of the protection Americans had against immunity.
Source: Daily Mail

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